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- Document 3092
- DOCN M94A3092
- TI Prognostic value of HIV-1 biological phenotype for survival after AIDS
- diagnosis.
- DT 9412
- AU Koot M; van Leeuwen R; Danner S; Schuitemaker H; Tersmette M; Reis P;
- Central Lab. Blood Transf., Amsterdam, The Netherlands.
- SO Int Conf AIDS. 1994 Aug 7-12;10(1):155 (abstract no. PB0046). Unique
- Identifier : AIDSLINE ICA10/94369483
- AB In about 50% of HIV-1 infected persons syncytium inducing (SI) HIV-1
- variants emerge during the asymptomatic phase of infection. The presence
- of SI variants in asymptomatic men is predictive for the progression to
- AIDS, independent of CD4+ T-cell numbers. Here we studied survival among
- AIDS patients in relation to HIV-1 phenotype CD4+ T-cell counts, and P24
- antigenemia. METHODS: In this study we included all AIDS patients (n =
- 218) who were diagnosed at the Academic Medical Centre between 1
- December 1985 and 1 December 1989. HIV-1 phenotype was determined by
- cocultivation of cryopreserved PBMC samples with MT-2 cells. RESULTS:
- Median CD4 count at the moment of AIDS diagnosis was 100/mm3. From 178
- out of 218 patients (82%) PBMC samples were available. In 89/178 persons
- (50.0%) SI HIV was detected. There was no significant difference between
- the patients with and without SI variants with respect to the number of
- P24 antigen positive persons or the number of zidovudine treated
- persons. However CD4 counts at the time of AIDS diagnosis were
- significantly lower in persons with SI variants (median: 100/mm3 vs.
- 200/mm3, p = 0.003). Zidovudine treatment, low CD4 counts and the
- presence of SI HIV-1 were predictive for decreased survival time in
- univariate cox analysis. Multivariate Cox analysis revealed prognostic
- value for zidovudine treatment and low CD4 counts only. Most (29/30)
- patients without SI HIV at AIDS diagnosis did not develop these variants
- during the final stage of disease. CONCLUSIONS: In agreement with
- previous published results about 50% of patients progressing to AIDS
- harbour SI viruses. These patients have significant lower CD4 counts at
- AIDS diagnosis. In this study population of AIDS patients the prognostic
- value of SI phenotype for survival could be explained by the association
- of SI variants with low CD4 counts at the moment of AIDS diagnosis.
- Emerge of SI variants after AIDS diagnosis was rarely observed even when
- the immune system is severely deteriorated.
- DE Acquired Immunodeficiency Syndrome/DRUG THERAPY/*MICROBIOLOGY/
- *MORTALITY Analysis of Variance Cell Line Comparative Study Human
- HIV Core Protein p24/BLOOD HIV Seropositivity/DRUG
- THERAPY/*MICROBIOLOGY/MORTALITY HIV-1/*GENETICS/ISOLATION & PURIF
- Leukocyte Count Lymphocytes/IMMUNOLOGY/MICROBIOLOGY Multivariate
- Analysis Phenotype Predictive Value of Tests Prognosis Survival Rate
- T4 Lymphocytes Zidovudine/THERAPEUTIC USE MEETING ABSTRACT
-
- SOURCE: National Library of Medicine. NOTICE: This material may be
- protected by Copyright Law (Title 17, U.S.Code).
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-